Use of Experimental Diffusion Coefficients To Probe Solute-Solute and Solute-Solvent Interactions in Electrolyte Solutions

Aqueous solutions of pyrimidine nucleic acid bases . Solute – solvent interactions

The data previously reported on the enthalpy of hydration, partial molar volumes and heat capacities of alkylated pyrimidine nucleic acid bases, e.g. uracil, thymine and cytosine, were correlated with the following structural parameters: molecular volume, volume of solvation shell, accessible molecular surface area and its atomic partition as well as and electrostatic potential charge. The simp...

Solvation of diclofenac in water from atomistic molecular dynamics simulations - interplay between solute-solute and solute-solvent interactions.

The solubility-permeability relationship of active pharmaceutical ingredients determines the efficacy of their usage. Diclofenac (DCL), which is a widely used nonsteroidal anti-inflammatory drug, is characterized by extremely good membrane permeability, but low water solubility limiting drug effectiveness. The present research focuses on the fundamental explanation of this limitation using the ...

Effects of solvent and solute drag on transmembrane diffusion

The present study compares and quantitates both solvent drag and solute drag forces in a system with both heteropore and homopore membranes. It is shown that tracer solute permeability can be increased if solution flow or driver solute flux is in the direction of tracer diffusion. Either force can decrease tracer permeability if the force can decrease tracer permeability if the force is opposit...

Elementary solute-solvent interactions and the photophysical properties of photoacids

Albendazole Solubilization in Aqueous Solutions of Nicotinamide: Thermodynamics and Solute Solvent Interactions

The present study deals with experiments so as to highlight the solute (drug albendazole) – solvent ( water) interactions and related thermodynamic modifications in presence of the hydrotropic agent nicotinamide at different temperatures T (= 298.15 to 313.15)K. Density and conductivity values of albendazole have been determined in water in (0.08 to 0.98) mol dm-3 aqueous solutions of nicotinam...